منابع مشابه
Identification of a structural and functional domain in xNAP1 involved in protein–protein interactions
xNAP1 (Xenopus nucleosome assembly protein) belongs to the family of nucleosome assembly proteins (NAPs) and shares 92% identity with human and mouse NAP1. NAPs have been reported to have a role in nucleosome assembly, cell cycle regulation, cell proliferation and transcriptional control, although the precise function of NAP1 is still not clear. Here we report the identification of a putative d...
متن کاملIdentification of neutralizing epitopes within structural domain III of the West Nile virus envelope protein.
Using a panel of neutralizing monoclonal antibodies, we have mapped epitopes in domain III of the envelope protein of the New York strain of West Nile virus. The ability of monoclonal antibodies that recognize these epitopes to neutralize virus appeared to differ between lineage I and II West Nile virus strains, and epitopes were located on the upper surface of domain III at residues E307, E330...
متن کاملAutomated Identification of Protein Structural Features
This paper proposes an iterative clustering procedure for finding protein motifs which do not necessarily correspond to secondary structures, or to features along the protein backbone. We show the applicability of our method to two important applications namely, protein structure matching, and automatically identifying active sites and other biologically significant sub-structures in proteins.
متن کاملProtein Family Databases for Automated Protein Domain Identification
Automatic identification and annotation of protein domains is a major challenge for genome sequencing projects. Simple transfer of the annotation from the overall most similar protein with a known function is relatively reliable for prokaryotic proteins, but often produces misleading and incomplete results for multi-domain proteins, which are common in higher organisms. An alternative approach ...
متن کاملDDBASE2.0: updated domain database with improved identification of structural domains
MOTIVATION Although many methods are available for the identification of structural domains from protein three-dimensional structures, accurate definition of protein domains and the curation of such data for a large number of proteins are often possible only after manual intervention. The availability of domain definitions for protein structural entries is useful for the sequence analysis of al...
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ژورنال
عنوان ژورنال: Protein Engineering, Design and Selection
سال: 1999
ISSN: 1741-0134,1741-0126
DOI: 10.1093/protein/12.3.203